You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

RAD9A (NM_001243224) - RAD9 checkpoint clamp component A

Cell Cycle Checkpoint Control Protein Rad9a Isoform 2

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of RAD9A protein. View all 2 isoforms
RAD9A: cell cycle checkpoint control protein RAD9A isoform 2
Description:

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Strand
+
Chromosome
11
Protein
315 residues
All mutations
72
PTM sites
17
CDS
67,160,960 - 67,165,030
Transcription
67,160,775 - 67,165,883
33.65% of sequence is predicted to be disordered

Usage summary

Network

drag the background to move whole network
scroll to zoom in and out

PTM site

double click to focus on site's sub-network (or hide it)

Kinases group

double click to show/hide all kinases within the group.

Kinase, PTM site or protein

hover to see a tooltip with additional information
click to stick the tooltip
drag a node to move it and stick in a chosen place
shift + click to free a node which was stuck earlier

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5883
UniProt
Ensembl