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PRKCQ (NM_001282645) - protein kinase C theta

Protein Kinase C Theta Type Isoform 4

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of PRKCQ protein. View all 4 isoforms
PRKCQ: protein kinase C theta type isoform 4
Description:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
10
Protein
581 residues
All mutations
105
PTM sites
41
CDS
6,470,168 - 6,552,960
Transcription
6,469,104 - 6,622,263
18.24% of sequence is predicted to be disordered

Usage summary

Network

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5588
UniProt
Ensembl