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THPO (NM_001289998) - thrombopoietin

Thrombopoietin Isoform 1 Precursor

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of THPO protein. View all 10 isoforms
THPO: thrombopoietin isoform 1 precursor
Description:

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014].

Strand
-
Chromosome
3
Protein
353 residues
All mutations
64
PTM sites
14
CDS
184,090,300 - 184,094,047
Transcription
184,089,722 - 184,097,476
22.1% of sequence is predicted to be disordered

Usage summary

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 7066
UniProt
Ensembl