PTPN11 (NM_002834) - protein tyrosine phosphatase non-receptor type 11
Tyrosine-Protein Phosphatase Non-Receptor Type 11 Isoform 1
Color corresponds to (the most severe) impact of mutations on given site:
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PTM Interaction Network Visualisation
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcript exon combination :: SRR1803611.69408.1, SRR1803611.229666.1 [ECO:0000332]
- 593 residues
- All mutations
- PTM sites
- 112,856,915 - 112,942,568
- 112,856,535 - 112,947,717
Kinase, PTM site or protein
- gene: 5781