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CHD3 (NM_005852) - chromodomain helicase DNA binding protein 3

Chromodomain-Helicase-Dna-Binding Protein 3 Isoform 2

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of CHD3 protein. View all 3 isoforms
CHD3: chromodomain-helicase-DNA-binding protein 3 isoform 2
Description:

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
17
Protein
1966 residues
All mutations
238
PTM sites
82
CDS
7,792,318 - 7,814,903
Transcription
7,792,168 - 7,816,075
45.83% of sequence is predicted to be disordered

Usage summary

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 1107
UniProt
Ensembl