PIK3CA (NM_006218) - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform
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Protein
Kinases
Sites
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Interactions
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PTM Interaction Network Visualisation
Protein summary
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Evidence data:
Transcript exon combination :: SRR1660805.126191.1, SRR1803615.87702.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]
- Strand
- +
- Chromosome
- 3
- Protein
- 1068 residues
- All mutations
- 288
- PTM sites
- 13
- CDS
- 178,916,613 - 178,952,152
- Transcription
- 178,866,310 - 178,952,497
Usage summary
Network
PTM site
Kinases group
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Kinase, PTM site or protein
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