MAPT (NM_016835) - microtubule associated protein tau

Microtubule-Associated Protein Tau Isoform 1

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of MAPT protein. View all 8 isoforms
MAPT: microtubule-associated protein tau isoform 1
Description:

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
17
Protein
758 residues
All mutations
174
PTM sites
58
CDS
44,039,703 - 44,101,537
Transcription
43,971,747 - 44,105,699
98.42% of sequence is predicted to be disordered

Usage summary

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 4137
Uniprot
Ensembl