You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

CDK1 (NM_033379) - cyclin dependent kinase 1

Cyclin-Dependent Kinase 1 Isoform 2

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of CDK1 protein. View all 4 isoforms
CDK1: cyclin-dependent kinase 1 isoform 2
Description:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Strand
+
Chromosome
10
Protein
240 residues
All mutations
21
PTM sites
33
CDS
62,539,923 - 62,553,733
Transcription
62,538,211 - 62,554,610
0.0% of sequence is predicted to be disordered

Usage summary

Network

drag the background to move whole network
scroll to zoom in and out

PTM site

double click to focus on site's sub-network (or hide it)

Kinases group

double click to show/hide all kinases within the group.

Kinase, PTM site or protein

hover to see a tooltip with additional information
click to stick the tooltip
drag a node to move it and stick in a chosen place
shift + click to free a node which was stuck earlier

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 983
UniProt
Ensembl