BACE2 (NM_138992) - beta-secretase 2
Beta-Secretase 2 Isoform B Preproprotein
Legend
Protein
Kinases
Sites
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PTM Interaction Network Visualisation
Protein summary
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
- Strand
- +
- Chromosome
- 21
- Protein
- 396 residues
- All mutations
- 50
- PTM sites
- 3
- CDS
- 42,540,190 - 42,647,354
- Transcription
- 42,539,727 - 42,654,461
Usage summary
Network
PTM site
Kinases group
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Kinase, PTM site or protein
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