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FAS (NM_152872) - Fas cell surface death receptor

Tumor Necrosis Factor Receptor Superfamily Member 6 Isoform 3 Precursor

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of FAS protein. View all 3 isoforms
FAS: tumor necrosis factor receptor superfamily member 6 isoform 3 precursor
Description:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].

Strand
+
Chromosome
10
Protein
220 residues
All mutations
45
PTM sites
10
CDS
90,750,633 - 90,773,887
Transcription
90,750,287 - 90,775,542
34.09% of sequence is predicted to be disordered

Usage summary

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 355
UniProt
Ensembl