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PPFIA1 (NM_177423) - PTPRF interacting protein alpha 1

Liprin-Alpha-1 Isoform A

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of PPFIA1 protein. View all 2 isoforms
PPFIA1: liprin-alpha-1 isoform a
Description:

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
11
Protein
1185 residues
All mutations
200
PTM sites
56
CDS
70,118,278 - 70,224,309
Transcription
70,116,805 - 70,224,598
63.8% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 8500
UniProt
Ensembl