After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.
For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
Pathways
Significant pathways lists were computed using the ActivePathways method which takes the p-values of genes in a pathway into consideration; this is a more powerful and stringent approach compared to ranking pathways by the number of significant genes alone (see Pathways with significant genes column), which was used in the initial release of ActiveDriverDB (and is still provided for reference).
Alternatively, you can browse a list of all pathways.
*) number of significant pathways/genes on the list