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ATR (NM_001184) - ATR serine/threonine kinase

Serine/threonine-Protein Kinase Atr Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of ATR protein.
ATR: serine/threonine-protein kinase ATR isoform 1
Description:

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017].

Strand
-
Chromosome
3
Protein
2644 residues
All mutations
397
PTM sites
73
CDS
142,168,270 - 142,297,546
Transcription
142,168,076 - 142,297,668
17.32% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 545
UniProt
Ensembl