STK11 (NM_000455) - serine/threonine kinase 11

Serine/threonine-Protein Kinase Stk11

Mutations Visualisation

Protein summary

This is preferred isoform of STK11 protein.
STK11: serine/threonine-protein kinase STK11
Description:

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1163655.336672.1, BC019334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348]

Strand
+
Chromosome
19
Protein
433 residues
All mutations
217
PTM sites
23
CDS
1,206,912 - 1,226,646
Transcription
1,205,797 - 1,228,434
18.48% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6794
Uniprot
Ensembl