TP53BP2 (NM_001031685) - tumor protein p53 binding protein 2

Apoptosis-Stimulating Of P53 Protein 2 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of TP53BP2 protein. View all 2 isoforms
TP53BP2: apoptosis-stimulating of p53 protein 2 isoform 1
Description:

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
1
Protein
1134 residues
All mutations
174
PTM sites
39
CDS
223,968,554 - 224,033,382
Transcription
223,967,594 - 224,033,674
66.14% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7159
Uniprot
Ensembl