CHD4 (NM_001273) - chromodomain helicase DNA binding protein 4

Chromodomain-Helicase-Dna-Binding Protein 4 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of CHD4 protein. View all 2 isoforms
CHD4: chromodomain-helicase-DNA-binding protein 4 isoform 1
Description:

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].

Strand
-
Chromosome
12
Protein
1912 residues
All mutations
253
PTM sites
93
CDS
6,679,841 - 6,715,539
Transcription
6,679,247 - 6,716,599
45.76% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 1108
Uniprot
Ensembl