CHEK1 (NM_001274) - checkpoint kinase 1

Serine/threonine-Protein Kinase Chk1 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of CHEK1 protein. View all 4 isoforms
CHEK1: serine/threonine-protein kinase Chk1 isoform 1
Description:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1803615.40036.1, BC017575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149178 [ECO:0000348]

Strand
+
Chromosome
11
Protein
476 residues
All mutations
55
PTM sites
34
CDS
125,496,663 - 125,525,215
Transcription
125,496,250 - 125,527,042
14.71% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 1111
Uniprot
Ensembl