MBD3 (NM_001281453) - methyl-CpG binding domain protein 3

Methyl-Cpg-Binding Domain Protein 3 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of MBD3 protein. View all 2 isoforms
MBD3: methyl-CpG-binding domain protein 3 isoform 1
Description:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].

Strand
-
Chromosome
19
Protein
291 residues
All mutations
56
PTM sites
14
CDS
1,578,338 - 1,592,630
Transcription
1,576,669 - 1,592,760
24.05% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 53615
Uniprot
Ensembl