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RPA2 (NM_001286076) - replication protein A2

Replication Protein A 32 Kda Subunit Isoform 2

Mutations Visualisation

Protein summary

This is an alternative isoform of RPA2 protein. View all 3 isoforms
RPA2: replication protein A 32 kDa subunit isoform 2
Description:

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017].

Strand
-
Chromosome
1
Protein
174 residues
All mutations
19
PTM sites
11
CDS
28,218,673 - 28,233,483
Transcription
28,218,035 - 28,241,308
12.07% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 6118
UniProt