HDAC2 (NM_001527) - histone deacetylase 2

Histone Deacetylase 2

Mutations Visualisation

Protein summary

This is preferred isoform of HDAC2 protein.
HDAC2: histone deacetylase 2
Description:

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

Strand
-
Chromosome
6
Protein
488 residues
All mutations
33
PTM sites
27
CDS
114,262,221 - 114,292,072
Transcription
114,257,319 - 114,292,359
20.49% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 3066
Uniprot
Ensembl