AKT2 (NM_001626) - AKT serine/threonine kinase 2

Rac-Beta Serine/threonine-Protein Kinase Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of AKT2 protein. View all 3 isoforms
AKT2: RAC-beta serine/threonine-protein kinase isoform 1
Description:

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
19
Protein
481 residues
All mutations
75
PTM sites
24
CDS
40,739,778 - 40,771,174
Transcription
40,736,223 - 40,791,302
24.12% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 208
Uniprot
Ensembl