CDK1 (NM_001786) - cyclin dependent kinase 1

Cyclin-Dependent Kinase 1 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of CDK1 protein. View all 4 isoforms
CDK1: cyclin-dependent kinase 1 isoform 1
Description:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Strand
+
Chromosome
10
Protein
297 residues
All mutations
23
PTM sites
37
CDS
62,539,923 - 62,553,733
Transcription
62,538,211 - 62,554,610
0.0% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 983
Uniprot
Ensembl