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CSNK2A2 (NM_001896) - casein kinase 2 alpha 2

Casein Kinase Ii Subunit Alpha'

Mutations Visualisation

Protein summary

This is preferred isoform of CSNK2A2 protein.
CSNK2A2: casein kinase II subunit alpha'
Description:

This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1163655.325568.1, SRR5189667.168546.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262506.8/ ENSP00000262506.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

Strand
-
Chromosome
16
Protein
350 residues
All mutations
30
PTM sites
21
CDS
58,197,974 - 58,231,640
Transcription
58,191,811 - 58,231,782
7.14% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 1459
UniProt
Ensembl