PPP2CA (NM_002715) - protein phosphatase 2 catalytic subunit alpha

Serine/threonine-Protein Phosphatase 2a Catalytic Subunit Alpha Isoform

Mutations Visualisation

Protein summary

This is preferred isoform of PPP2CA protein.
PPP2CA: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Description:

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1660809.9460.1, SRR1660809.218129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820687, SAMN03267764 [ECO:0000348]

Strand
-
Chromosome
5
Protein
309 residues
All mutations
24
PTM sites
19
CDS
133,533,462 - 133,561,552
Transcription
133,532,147 - 133,561,950
6.8% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5515
Uniprot
Ensembl