PPP2R1B (NM_002716) - protein phosphatase 2 scaffold subunit Abeta

Serine/threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Beta Isoform Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of PPP2R1B protein. View all 5 isoforms
PPP2R1B: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a
Description:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

Strand
-
Chromosome
11
Protein
601 residues
All mutations
85
PTM sites
21
CDS
111,612,319 - 111,637,085
Transcription
111,608,604 - 111,637,169
3.49% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5519
Uniprot
Ensembl