MAP2K6 (NM_002758) - mitogen-activated protein kinase kinase 6

Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of MAP2K6 protein.
MAP2K6: dual specificity mitogen-activated protein kinase kinase 6 isoform 1
Description:

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1803612.290913.1, SRR1803611.10378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348]

Strand
+
Chromosome
17
Protein
334 residues
All mutations
31
PTM sites
11
CDS
67,411,125 - 67,537,894
Transcription
67,410,837 - 67,538,470
10.18% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5608
Uniprot
Ensembl