MAP2K6 (NM_002758) - mitogen-activated protein kinase kinase 6
Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 Isoform 1
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This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcript exon combination :: SRR1803612.290913.1, SRR1803611.10378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348]
- 334 residues
- All mutations
- PTM sites
- 67,411,125 - 67,537,894
- 67,410,837 - 67,538,470