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PYGB (NM_002862) - glycogen phosphorylase B

Glycogen Phosphorylase, Brain Form

Mutations Visualisation

Protein summary

This is preferred isoform of PYGB protein.
PYGB: glycogen phosphorylase, brain form
Description:

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1803617.211977.1, SRR1660807.231969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216962.9/ ENSP00000216962.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

Strand
+
Chromosome
20
Protein
843 residues
All mutations
158
PTM sites
50
CDS
25,228,814 - 25,277,158
Transcription
25,228,705 - 25,278,648
3.2% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5834
UniProt
Ensembl