RBBP7 (NM_002893) - RB binding protein 7, chromatin remodeling factor

Histone-Binding Protein Rbbp7 Isoform 2

Mutations Visualisation

Protein summary

This is preferred isoform of RBBP7 protein. View all 2 isoforms
RBBP7: histone-binding protein RBBP7 isoform 2
Description:

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

Strand
-
Chromosome
X
Protein
425 residues
All mutations
38
PTM sites
24
CDS
16,863,157 - 16,888,176
Transcription
16,862,774 - 16,888,534
11.76% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5931
Uniprot
Ensembl