RBBP8 (NM_002894) - RB binding protein 8, endonuclease

Dna Endonuclease Rbbp8 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of RBBP8 protein. View all 3 isoforms
RBBP8: DNA endonuclease RBBP8 isoform a
Description:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
18
Protein
897 residues
All mutations
123
PTM sites
34
CDS
20,516,814 - 20,606,203
Transcription
20,513,294 - 20,606,449
63.99% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5932
Uniprot
Ensembl