RFC4 (NM_002916) - replication factor C subunit 4

Replication Factor C Subunit 4

Mutations Visualisation

Protein summary

This is preferred isoform of RFC4 protein. View all 2 isoforms
RFC4: replication factor C subunit 4
Description:

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
3
Protein
363 residues
All mutations
80
PTM sites
19
CDS
186,507,757 - 186,522,502
Transcription
186,507,681 - 186,524,290
9.92% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5984
Uniprot
Ensembl