RPS27A (NM_002954) - ribosomal protein S27a

Ubiquitin-40s Ribosomal Protein S27a Precursor

Mutations Visualisation

Protein summary

This is preferred isoform of RPS27A protein. View all 3 isoforms
RPS27A: ubiquitin-40S ribosomal protein S27a precursor
Description:

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008].

Strand
+
Chromosome
2
Protein
156 residues
All mutations
14
PTM sites
24
CDS
55,459,960 - 55,462,713
Transcription
55,459,540 - 55,462,989
5.77% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6233
Uniprot
Ensembl