SSRP1 (NM_003146) - structure specific recognition protein 1
Fact Complex Subunit Ssrp1
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The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008].
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcript exon combination :: M86737.1, SRR1803615.37174.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
- 709 residues
- All mutations
- PTM sites
- 57,093,880 - 57,102,595
- 57,093,458 - 57,103,351