SSRP1 (NM_003146) - structure specific recognition protein 1

Fact Complex Subunit Ssrp1

Mutations Visualisation

Protein summary

This is preferred isoform of SSRP1 protein.
SSRP1: FACT complex subunit SSRP1
Description:

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: M86737.1, SRR1803615.37174.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
11
Protein
709 residues
All mutations
77
PTM sites
65
CDS
57,093,880 - 57,102,595
Transcription
57,093,458 - 57,103,351
33.57% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6749
Uniprot
Ensembl