USP7 (NM_003470) - ubiquitin specific peptidase 7

Ubiquitin Carboxyl-Terminal Hydrolase 7 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of USP7 protein. View all 3 isoforms
USP7: ubiquitin carboxyl-terminal hydrolase 7 isoform 1
Description:

The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016].

Strand
-
Chromosome
16
Protein
1102 residues
All mutations
115
PTM sites
26
CDS
8,987,854 - 9,057,142
Transcription
8,985,950 - 9,057,341
7.08% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7874
Uniprot
Ensembl