AURKA (NM_003600) - aurora kinase A

Aurora Kinase A

Mutations Visualisation

Protein summary

This is preferred isoform of AURKA protein. View all 6 isoforms
AURKA: aurora kinase A
Description:

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
20
Protein
403 residues
All mutations
46
PTM sites
26
CDS
54,945,213 - 54,963,253
Transcription
54,944,444 - 54,967,351
33.75% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6790
Uniprot
Ensembl