USP2 (NM_004205) - ubiquitin specific peptidase 2

Ubiquitin Carboxyl-Terminal Hydrolase 2 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of USP2 protein. View all 3 isoforms
USP2: ubiquitin carboxyl-terminal hydrolase 2 isoform a
Description:

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

Strand
-
Chromosome
11
Protein
605 residues
All mutations
108
PTM sites
3
CDS
119,227,544 - 119,244,190
Transcription
119,225,924 - 119,252,436
43.64% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 9099
Uniprot
Ensembl