HUS1 (NM_004507) - HUS1 checkpoint clamp component

Checkpoint Protein Hus1

Mutations Visualisation

Protein summary

This is preferred isoform of HUS1 protein.
HUS1: checkpoint protein HUS1
Description:

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].

Strand
-
Chromosome
7
Protein
280 residues
All mutations
40
PTM sites
4
CDS
48,004,952 - 48,019,116
Transcription
48,002,884 - 48,019,222
3.57% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 3364
Uniprot
Ensembl