RAD9A (NM_004584) - RAD9 checkpoint clamp component A

Cell Cycle Checkpoint Control Protein Rad9a Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of RAD9A protein. View all 2 isoforms
RAD9A: cell cycle checkpoint control protein RAD9A isoform 1
Description:

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Strand
+
Chromosome
11
Protein
391 residues
All mutations
82
PTM sites
16
CDS
67,159,515 - 67,165,030
Transcription
67,159,422 - 67,165,883
27.88% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5883
Uniprot
Ensembl