TOP3A (NM_004618) - topoisomerase (DNA) III alpha

Dna Topoisomerase 3-Alpha Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of TOP3A protein.
TOP3A: DNA topoisomerase 3-alpha isoform 1
Description:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].

Strand
-
Chromosome
17
Protein
1001 residues
All mutations
158
PTM sites
7
CDS
18,178,115 - 18,218,092
Transcription
18,177,234 - 18,218,321
21.38% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7156
Uniprot
Ensembl