MTA2 (NM_004739) - metastasis associated 1 family member 2

Metastasis-Associated Protein Mta2 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of MTA2 protein.
MTA2: metastasis-associated protein MTA2 isoform 1

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: BC053650.1, SRR1660805.229003.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

668 residues
All mutations
PTM sites
62,361,346 - 62,368,922
62,360,674 - 62,369,312
35.93% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
gene: 9219