CDK5 (NM_004935) - cyclin dependent kinase 5

Cyclin-Dependent-Like Kinase 5 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of CDK5 protein. View all 2 isoforms
CDK5: cyclin-dependent-like kinase 5 isoform 1
Description:

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

Strand
-
Chromosome
7
Protein
292 residues
All mutations
33
PTM sites
15
CDS
150,751,095 - 150,754,935
Transcription
150,750,898 - 150,755,052
0.0% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 1020
Uniprot
Ensembl