HDAC1 (NM_004964) - histone deacetylase 1
Histone Deacetylase 1
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Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcript exon combination :: D50405.1, SRR1803611.177301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]
- 482 residues
- All mutations
- PTM sites
- 32,757,770 - 32,798,645
- 32,757,707 - 32,799,224