PIP4K2A (NM_005028) - phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of PIP4K2A protein.
PIP4K2A: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1
Description:

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
10
Protein
406 residues
All mutations
53
PTM sites
10
CDS
22,826,129 - 23,003,255
Transcription
22,823,765 - 23,003,503
19.46% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5305
Uniprot
Ensembl