PRKAB2 (NM_005399) - protein kinase AMP-activated non-catalytic subunit beta 2

5'-Amp-Activated Protein Kinase Subunit Beta-2

Mutations Visualisation

Protein summary

This is preferred isoform of PRKAB2 protein.
PRKAB2: 5'-AMP-activated protein kinase subunit beta-2
Description:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013].

Strand
-
Chromosome
1
Protein
272 residues
All mutations
21
PTM sites
16
CDS
146,631,143 - 146,643,723
Transcription
146,626,684 - 146,644,168
26.47% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5565
Uniprot
Ensembl