AKT3 (NM_005465) - AKT serine/threonine kinase 3

Rac-Gamma Serine/threonine-Protein Kinase Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of AKT3 protein. View all 3 isoforms
AKT3: RAC-gamma serine/threonine-protein kinase isoform 1
Description:

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
1
Protein
479 residues
All mutations
63
PTM sites
15
CDS
243,668,550 - 244,006,472
Transcription
243,663,020 - 244,006,584
16.91% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 10000
Uniprot
Ensembl