MRE11A (NM_005591) - MRE11 homolog, double strand break repair nuclease

Double-Strand Break Repair Protein Mre11 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of MRE11A protein. View all 2 isoforms
MRE11A: double-strand break repair protein MRE11 isoform 1
Description:

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1803612.102131.1, SRR1660805.35065.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
11
Protein
708 residues
All mutations
280
PTM sites
51
CDS
94,153,290 - 94,225,967
Transcription
94,150,468 - 94,227,040
30.79% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 4361
Uniprot
Ensembl