MRE11A (NM_005591) - MRE11 homolog, double strand break repair nuclease
Double-Strand Break Repair Protein Mre11 Isoform 1
Legend
Mutation impacts
Sites
- C-linked
- N-linked
- O-linked
- S-linked
- SARS-CoV-2
Others
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Mutations Visualisation
Protein summary
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments.
Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Evidence data:
Transcript exon combination :: AF022778.1, SRR1803614.132843.1 [ECO:0000332]
- Strand
- -
- Chromosome
- 11
- Protein
- 708 residues
- All mutations
- 598
- PTM sites
- 68
- CDS
- 94,153,290 - 94,225,967
- Transcription
- 94,150,468 - 94,227,040