RBBP4 (NM_005610) - RB binding protein 4, chromatin remodeling factor

Histone-Binding Protein Rbbp4 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of RBBP4 protein. View all 3 isoforms
RBBP4: histone-binding protein RBBP4 isoform a
Description:

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

Strand
+
Chromosome
1
Protein
425 residues
All mutations
32
PTM sites
17
CDS
33,116,907 - 33,145,306
Transcription
33,116,748 - 33,151,812
11.76% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5928
Uniprot
Ensembl