SGK1 (NM_005627) - serum/glucocorticoid regulated kinase 1

Serine/threonine-Protein Kinase Sgk1 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of SGK1 protein. View all 5 isoforms
SGK1: serine/threonine-protein kinase Sgk1 isoform 1
Description:

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

Strand
-
Chromosome
6
Protein
431 residues
All mutations
57
PTM sites
9
CDS
134,491,405 - 134,495,945
Transcription
134,490,383 - 134,496,034
20.88% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6446
Uniprot
Ensembl