TAF6 (NM_005641) - TATA-box binding protein associated factor 6

Transcription Initiation Factor Tfiid Subunit 6 Isoform Alpha

Mutations Visualisation

Protein summary

This is preferred isoform of TAF6 protein. View all 3 isoforms
TAF6: transcription initiation factor TFIID subunit 6 isoform alpha
Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

Strand
-
Chromosome
7
Protein
677 residues
All mutations
89
PTM sites
21
CDS
99,704,868 - 99,711,832
Transcription
99,704,692 - 99,716,995
38.4% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6878
Uniprot
Ensembl