TAF11 (NM_005643) - TATA-box binding protein associated factor 11

Transcription Initiation Factor Tfiid Subunit 11 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of TAF11 protein. View all 2 isoforms
TAF11: transcription initiation factor TFIID subunit 11 isoform 1
Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

Strand
-
Chromosome
6
Protein
211 residues
All mutations
27
PTM sites
3
CDS
34,846,366 - 34,855,734
Transcription
34,845,554 - 34,855,848
49.29% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6882
Uniprot
Ensembl