TAF12 (NM_005644) - TATA-box binding protein associated factor 12

Transcription Initiation Factor Tfiid Subunit 12

Mutations Visualisation

Protein summary

This is preferred isoform of TAF12 protein. View all 2 isoforms
TAF12: transcription initiation factor TFIID subunit 12
Description:

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008].

Strand
-
Chromosome
1
Protein
161 residues
All mutations
16
PTM sites
3
CDS
28,930,050 - 28,948,593
Transcription
28,929,608 - 28,969,604
32.92% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 6883
Uniprot
Ensembl